Researchers at The Hong Kong Polytechnic University (PolyU) has developed new optical fibre biosensors made from advanced plastic material, ZEONEX, which open new possibilities for medical applications, from improving surgery precision to providing novel ways of monitoring human body recovery from within the body.
“The new plastic optical fibre sensors can detect extremely subtle changes even of a difference smaller than 1 per cent of atmospheric pressure – sensitive enough to measure pressure inside the lungs while breathing, which changes by just a few kilopascals,” said Professor Hwa-yaw Tam, chair professor of photonics and head of the Department of Electrical Engineering at PolyU, who led the research team that developed the new fibre optic microsensors.
The new “Side Hole Polymer Optical Fibre Sensors” are biocompatible and could be made as small as a few micrometres. Their sensitivity to pressure is twenty times that of traditional optical fibre sensors. They are deemed to be the most advanced railway safety monitoring technologies available for medical surveillance inside the human body.
Optical fibres are not just for transmission – they are also good sensors for detecting external changes by observing the reflection of the light beams passing through them. There is also growing use of fibre optics technology in medical applications, such as in surgical instrumentation, diagnostic and imaging equipment, or sensor-based wearable medical devices.
However, to deploy fibre optic sensing technology for monitoring inside the human body, traditional optical fibres made of glass or plastic have major drawbacks – glass is too stiff and brittle, while traditional plastic fibres tend to absorb water. Furthermore, the optical fibre sensors need to be able to detect very subtle changes for the purpose of medical monitoring.
The new sensors develop by PolyU solves the problems posed by glass and traditional plastic. In addition, the new sensor is made more sensitive by adding a side hole running in parallel with the light transmission path inside the optical fibre.
New medical applications
Tam believes the new sensors will enable whole new applications for medical monitoring inside the human body not available before. These include include smart cochlear implantation, bone fracture recovery monitoring, or navigation monitoring in cardiac catheterisation.
“They are humidity insensitive, supple and shatter-resistant. They are also chemically inert, biocompatible, and can be made super tiny in size. These unique features make the sensors ideal for integration with medical implants,” he said.
Already, the PolyU research team is working with counterparts from Australian and Japanese universities to develop various sensors for medical monitoring applications.
For instance, a smart cochlear implant featuring the PolyU tiny sensors could provide critical information about location and force to surgeons in real time during the implantation procedure. The smart cochlear implant will commence in vitro testing at the University of Melbourne and the Royal Victorian Eye and Ear Hospital.
PolyU is also working with Monash University researchers to integrate fibre sensors in orthopaedic implants for monitoring bone fracture recovery.
The PolyU research team will continue to explore further medical monitoring applications using the new plastic fibre optic sensors, including their use for precise navigation and shape detection in cardiac catheterisation.
Professor Tam and his team are also working to expand the sensors’ ability to measure other physical or chemical changes like acidity and temperature.
“We also seek to develop a sensing network that integrates our sensors with emerging technologies like the wireless Internet-of-Things. The sensing network would be able to give a comprehensive and precise picture of changes inside the human body, thus helping patients around the world via technological innovation,” he said.
The “Side Hole Polymer Optical Fibre Sensors” research findings were published earlier this year in Optics Letters by US-based The Optical Society. Part of the jointly developed applications with other universities have already been granted patents.
